Project Description
- Polymorphic nucleation and transformation in batch crystallization;
- Polymorphic control in continuous crystallization;
- Additive effects on crystal shape and polymorphs.
Publications and Presentations
Journal Publications
Zhang T,Liu Y, Du S, et al. Polymorph Control by Investigating the Effects of Solvent and Supersaturation on Clopidogrel Hydrogen Sulfate in Reactive Crystallization, Crystal Growth and Design. 2017,17(11)
Wang Y, Sun, P., Xu, S., Du, S.,Zhang T., & Yu, B., et al. Solution-mediated phase transformation of argatroban: ternary phase diagram, rate-determining step, and transformation kinetics. Industrial & Engineering Chemistry Research. 2017
Li Z, Zhang T, Huang C, et al. Measurement and Correlation of the Solubility of Maltitol in Different Pure Solvents, Methanol–Water Mixtures, and Ethanol–Water Mixtures. Journal of Chemical & Engineering Data. 2016, 61(3).
Zhang T,Li Z, Wang Y, et al. Determination and correlation of solubility and thermodynamic properties of l -methionine in binary solvents of water + (methanol, ethanol, acetone), Journal of Chemical Thermodynamics. 2016,96:82-92
Conference Presentation
“Polymorph screening of Clopidogrel Hydrogen Sulfate (CHS) using Reactive Crystallization Process Control Technology”, 24th International Workshop on Industrial Crystallization (BIWIC), Dortmund, Germany, Aug. 2017 (oral)
Education
|
